The Inbox on your Dashboard screen houses any system notifications that have been sent for your attention. Here's how you can clear out your Inbox and address any To Dos that need your attention:
To open the To Do simply click on the name.
Once opened you will see all details of the To Do including any requests that need approved, documents that need reviewed and any E-Signature requirements.
Once you have reviewed any of the information in the To Do you can click the button at the top to either Acknowledge or Approve/Reject. If you wish to respond later you can click "Mark as New" which will leave the To Do in your Inbox.